Talk to your doctor about serious side effects, including:– Kidney problems (acute interstitial nephritis) may happen at any time during treatment with NEXIUM. Call your doctor if you have a decrease in the amount that you urinate or if you have blood in your urine
– NEXIUM may increase your risk of getting severe diarrhea. Call your doctor right away if you have watery stool, stomach pain and fever that does not go away
– Bone fractures if you take multiple daily doses of NEXIUM for a year or longer
– Some people who take PPIs, including NEXIUM, develop certain types of lupus or have worsening of the lupus they already have. Call your doctor right away if you have joint pain or rash on your cheeks or arms that gets worse in the sun
– Low vitamin B12 if you have been on NEXIUM for a long time (more than 3 years)
– Low magnesium levels if you take NEXIUM (for 3 months or more)
– Stomach growths (fundic gland polyps), especially if you take PPIs for more than 1 year