How to mix and administer

Prepared in just minutes, once a day

For oral administration

Simply mix packet contents with water* to prepare NEXIUM Packets

  • Add the appropriate amount of water* for the prescribed dose to a container:
    • 5 mL of water for the 2.5-mg or 5-mg doses

      5 mL = 1 teaspoon

    • 15 mL of water* for the 10-mg, 20-mg, or 40-mg doses

      15 mL = 1 tablespoon

    *NEXIUM Packets can be mixed with applesauce. Use with other foods is not recommended.

  • Doses for infants and children may range from 2.5 mg to 40 mg. Adult doses may be 20 mg or 40 mg.

  • Empty the contents of a foil packet of NEXIUM Packets containing the dose prescribed by the doctor into the container of water.
  • Stir and leave 2 to 3 minutes to thicken.
  • Stir again and drink the dose within 30 minutes.
Preparation for oral administration of NEXIUM Packets

If medicine is not used within 30 minutes, throw away the dose and mix a new one. If any medicine remains after drinking, add more water, stir, and make sure the dose is taken right away.

For young children, you can give the dose with an oral syringe. Rinse the oral syringe with water after each use.

For administration through a nasogastric (NG) or gastric tube

  • Can be prepared for administration into an NG or gastric tube in just minutes

Please see the Medication Guide in the full Prescribing Information for administration details.


  • Symptom relief does not rule out the presence of other serious conditions. Talk with your doctor
  • Talk to your doctor about serious side effects, including:

    – Kidney problems (acute interstitial nephritis) may happen at any time during treatment with NEXIUM. Call your doctor if you have a decrease in the amount that you urinate or if you have blood in your urine

    – NEXIUM may increase your risk of getting severe diarrhea. Call your doctor right away if you have watery stool, stomach pain and fever that does not go away

    – Bone fractures if you take multiple daily doses of NEXIUM for a year or longer

    – Some people who take PPIs, including NEXIUM, develop certain types of lupus or have worsening of the lupus they already have. Call your doctor right away if you have joint pain or rash on your cheeks or arms that gets worse in the sun

    – Low vitamin B12 if you have been on NEXIUM for a long time (more than 3 years)

    – Low magnesium levels if you take NEXIUM (for 3 months or more)

    – Stomach growths (fundic gland polyps), especially if you take PPIs for more than 1 year

  • Tell your doctor about all of the medicines you take, prescription and nonprescription drugs, including clopidogrel, vitamins and herbal supplements. NEXIUM may affect how other medicines work and other medicines may affect how NEXIUM works
  • Do not take NEXIUM if you are allergic to esomeprazole magnesium or any of the ingredients in NEXIUM or are allergic to any other PPI
  • The most common side effects with NEXIUM may include headache, diarrhea, nausea, gas, abdominal pain, constipation, dry mouth and drowsiness
  • In adults 18 and older, the most common side effects with NEXIUM may include headache, diarrhea, nausea, gas, abdominal pain, constipation, and dry mouth
  • In children 1 to 17 years of age, the most common side effects with NEXIUM may include headache, diarrhea, abdominal pain, nausea, and drowsiness

APPROVED USES FOR NEXIUM® (esomeprazole magnesium)

NEXIUM is prescribed to treat the symptoms of acid reflux disease, which typically include persistent heartburn on 2 or more days per week, despite treatment and change of diet.

For many people, NEXIUM is also prescribed to heal damage to the esophagus called erosive esophagitis. This damage may be caused over time from stomach acid wearing away the lining of the esophagus. Only a doctor can diagnose this condition. With NEXIUM, most erosions heal in 4 to 8 weeks. Your results with NEXIUM may vary.

Please read full Prescribing Information, Medication Guide and Instructions for Use for NEXIUM Packets.

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