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NEXIUM Packets is covered without prior authorization for the majority of Commercial and Medicare Part D patients nationwide1/2*†

Additional Important Formulary Information/ References

*"Patients" means covered lives (Commercial, Commercial [BCBS], Employer, Medicare MA, Medicare PDP, Medicare SN, Municipal Plan, PBM, Union) at Tiers 1-7 in the region/nation, as calculated by Fingertip Formulary® as of Month Day,Year.

†“Covered without prior authorization” means that additional information is not required to be provided to the health plan in order for NEXIUM to be covered. Step edits may apply.

Individual benefit design may vary. Please consult with individual plans for specific information.

 

AstraZeneca does not endorse any individual, commercial, Medicare Part D, or Medicaid plan or plans.

Individual benefit design may vary. Please consult with individual plans for specific information.

Formulary comparisons do not imply comparable efficacy, safety or FDA-approved indications.

With the NEXIUM savings card, your patients can pay just $15 a month or $30 for a 90-day supply of prescription NEXIUM.*

* Eligible customers can save up to $125 per 30-day supply. Individual out-of-pocket costs may vary. Program eligibility and restrictions apply. Please see offer for details. Offer void for prescriptions purchased under Medicaid, Medicare, or similar state or federally funded, sponsored, or supported programs (other than FEHBP) and is void where prohibited by law, taxed, or restricted.

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Important Safety Information for NEXIUM® (esomeprazole magnesium)

  • NEXIUM is contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted benzimidazoles
  • Symptomatic response to therapy does not rule out the presence of gastric malignancy. Consider additional follow-up and diagnostic testing in adult patients who have a suboptimal response or an early symptomatic relapse after completing treatment with a proton pump inhibitor (PPI). In older patients, also consider an endoscopy
  • Acute interstitial nephritis has been observed in patients taking PPIs including NEXIUM. Discontinue NEXIUM if acute interstitial nephritis develops
  • PPI therapy may be associated with increased risk of Clostridium difficile-associated diarrhea. This diagnosis should be considered for diarrhea that does not improve
  • PPI therapy may be associated with an increased risk of osteoporosis-related fractures of the hip, wrist, or spine. The risk of fracture was increased in patients who received high-dose (multiple daily doses) and long-term (a year or longer) therapy
  • Cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE) have been reported in patients taking PPIs, including esomeprazole. These events included both new onset and exacerbations. If signs or symptoms consistent with CLE or SLE are noted with NEXIUM, discontinue and refer the patient to a specialist. Most patients improve with discontinuation of the PPI alone in 4 to 12 weeks
  • Avoid concomitant use of NEXIUM with clopidogrel, due to a reduction in plasma concentrations of the active metabolite of clopidogrel. When using NEXIUM consider alternative anti-platelet therapy
  • Daily treatment with any acid-suppressing medications over a long period of time (eg, longer than 3 years) may lead to malabsorption of cyanocobalamin (vitamin B12). Rare reports of cyanocobalamin deficiency occurring with acid-suppressing therapy have been reported in the literature
  • Hypomagnesemia has been reported rarely with prolonged treatment with PPI therapy and may require discontinuing PPI therapy
  • Concomitant use of NEXIUM and St. John’s wort or rifampin can substantially decrease NEXIUM concentrations. Avoid concomitant use
  • Literature suggests that concomitant use of PPIs with methotrexate (primarily at high dose; see methotrexate prescribing information) may elevate and prolong serum levels of methotrexate and/or its metabolite, possibly leading to methotrexate toxicities. In high-dose methotrexate administration, a temporary withdrawal of the PPI may be considered in some patients
  • Concomitant use of NEXIUM and atazanavir or nelfinavir is not recommended. NEXIUM is expected to increase the plasma levels of saquinavir. Consider dose reduction of saquinavir
  • Patients treated with PPIs and warfarin concomitantly may need to be monitored for increases in INR and prothrombin time. Esomeprazole may interfere with the absorption of drugs for which gastric pH affects bioavailability (eg, ketoconazole, iron salts, and digoxin)
  • NEXIUM may increase systemic exposure of cilostazol and one of its active metabolites. Consider dose reduction of cilastozol
  • NEXIUM I.V. should be used only when oral therapy with NEXIUM is not possible or appropriate
  • In adults, the most frequently reported adverse reactions (ARs) with NEXIUM include headache, diarrhea, and abdominal pain
  • The ARs reported at a frequency of 1% or greater with NEXIUM I.V. in clinical trials were headache, flatulence, nausea, abdominal pain, injection site reaction, diarrhea, dry mouth, dizziness/vertigo, constipation, and pruritus
  • In pediatric patients 1 to 17 years of age, the most frequently reported ARs with NEXIUM include headache, diarrhea, abdominal pain, nausea, and somnolence
  • In pediatric patients 1 to 11 months the most frequently reported ARs with NEXIUM include abdominal pain, regurgitation, tachypnea, and increased ALT

Indications for NEXIUM® (esomeprazole magnesium)

  • NEXIUM is indicated for short-term treatment (4 to 8 weeks) in healing and symptomatic resolution of diagnostically confirmed erosive esophagitis (EE). NEXIUM is indicated to maintain symptom resolution and healing of EE (controlled studies did not extend beyond 6 months), and for short-term treatment (4 to 8 weeks) of heartburn and other symptoms associated with GERD
  • NEXIUM is indicated for the short-term treatment (4 to 8 weeks) of heartburn and other symptoms associated with GERD in adults and children 1 year and older
  • In infants 1 month to less than 1 year, NEXIUM is indicated for the short-term treatment (up to 6 weeks) of erosive esophagitis due to acid mediated gastroesophageal reflux disease (GERD)
  • The safety and effectiveness of NEXIUM for patients younger than 1 month has not been established

Please read full Prescribing Information, Medication Guide and Instructions for Use for NEXIUM Packets.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.1-800-FDA-1088.

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